10/24/2023 0 Comments Who detached licence chimera tool![]() ![]() From here, we have selected 20 compounds those were good in terms of pharmacokinetic parameters. The resulting analysis of virtual screening suggested that 404 compounds show good binding affinity and can be employed for pharmacokinetic analysis. ![]() We have retrieved a set of compounds ( n=167,741) and screened against GSK-3 β in four sequential steps. ![]() In this study, we have used a series of computational approaches to find novel inhibitors against GSK-3 β to reduce the TAU hyperphosphorylation. ![]() The glycogen synthase kinase 3 beta plays a major role in the hyperphosphorylation of tau protein which forms the neurofibrillary tangles which is a major hallmark of AD. AD is a very complex disease and the drugs available in the market cannot fully cure it. Alzheimer’s disease is a leading neurodegenerative disease worldwide and is the 6th leading cause of death in the USA.
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